| ISCE 2007 Session I: The Electrophysiology and Electrocardiography of Heart Failure and Myocardial Infarction |
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Author(s) |
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Structural and electrical remodeling as therapeutic targets in heart failure
Abstract: Heart failure is a progressive clinical syndrome that is characterized by remodeling of the myocardium in response to various stress signals. The past several years has seen remarkable progr...
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Michael J. Cutler,
David S. Rosenbaum,
Mark E. Dunlap
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S1-S7
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Cellular basis for triggered ventricular arrhythmias that occur in the setting of compensated hypertrophy and heart failure: considerations for diagnosis and treatment
Abstract: Malignant ventricular tachyarrhythmias are common among patients with hypertrophy and heart failure, and these arrhythmias can initiate by triggered activity. Abnormal repolarization and dis...
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Gudrun Antoons,
Avram Oros,
Virginie Bito,
Karin R. Sipido,
Marc A. Vos
et al.
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S8-S14
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Estimated body surface potential maps in emergency department patients with unrecognized transient myocardial ischemia
Abstract: Background: We report on 5 patients who presented to the emergency department (ED) with chest pain, had negative serum troponin levels, and were discharged with a presumed noncardiac diagnos...
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Barbara J. Drew,
Daniel M. Schindler,
Jessica K. Zegre,
Kirsten E. Fleischmann,
Robert L. Lux
et al.
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S15-S20
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Electrocardiographic manifestation of anatomical substrates underlying post–myocardial infarction tachycardias
Abstract: There are great differences in the type of fibrosis that composes an infarcted area. The type of fibrosis will affect the characteristics of recorded extracellular electrograms. Patchy fibro...
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Jacques M.T. de Bakker,
Harold V.M. van Rijen
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S21-S25
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Genetic predisposition and cellular basis for ischemia-induced ST-segment changes and arrhythmias
Abstract: Recent reports have highlighted the importance of a family history of sudden death as a risk for ventricular fibrillation (VF) in patients experiencing acute myocardial infarction (AMI), poi...
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Dan Hu,
Sami Viskin,
Antonio Oliva,
Jonathan M. Cordeiro,
Alejandra Guerchicoff,
Guido D. Pollevick,
Charles Antzelevitch
et al.
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S26-S29
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Performance study of textile electrocardiogram electrodes based on heart rate variability
The electrode is the weakest link in the acquisition chain of an electrocardiogram (ECG), and its performance has a large impact on the signal quality. Silver/Silver chloride (Ag/AgCl) electrodes are ...
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Roger Abächerli,
Remo Leber,
Michael Keller,
Markus Weder,
Renato Ferrario,
André Sulser,
Hans-Jörg Zweifel,
Johann-Jakob Schmid
et al.
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S30
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Circadian rhythm of ventricular response during atrial fibrillation is not determined by dual atrioventricular nodal pathway conduction
Atrial fibrillation (AF) is characterized by an unorganized electrical activity of the atria and irregular atrioventricular (AV) conduction leading to irregular ventricular responses (RR intervals) wi...
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Andreu M. Climent,
M. Salud Guillem,
Daniela Husser,
Francisco Castells,
Jose Millet,
Andreas Bollmann
et al.
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S30
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Synchronizing transthoracic shocks for VF to the surface electrocardiogram does not improve defibrillation success
Optimization of defibrillation success is important to improve efficacy and minimize postshock sequelae. Previous work has suggested an improvement in shock success when an intracardiac shock is deliv...
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K.M. Darragh,
G. Manoharan,
C. Navarro,
S.J. Walsh,
J.D. Allen,
J. Anderson,
A.A.J. Adgey
et al.
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S30-S31
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A novel low-tilt biphasic waveform is efficacious with significantly lower voltage and current than a standard waveform in the defibrillation of VF
Previous work in atrial fibrillation has suggested that the use of low-tilt waveforms improves defibrillation success with significantly lower delivered voltage (V) and current (I). We hypothesize tha...
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K.M. Darragh,
C. Doyle,
S.J. Walsh,
J.D. Allen,
A.A.J. Adgey,
J. Anderson,
G. Manoharan
et al.
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S31
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Computerized acoustic cardiographic electromechanical activation time correlates with invasive and echocardiographic parameters of left ventricular contractility
The ability to detect left ventricular systolic dysfunction is important because it frequently provides the pathophysiologic substrate for heart failure, a major cause of disability and death. Current...
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Stilianos Efstratiadis,
Eric Palfreyman,
Mia Shapiro,
Sarah G. Weeks,
Elyse Foster,
Andrew D. Michaels
et al.
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S31
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Design of a novel, long-term, arrhythmia monitor
Achieving reliable, long-term electrocardiogram (ECG) monitoring for diagnosing infrequent arrhythmias requires innovative balancing of technical aspects of ECG acquisition with ease of use by untrain...
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S. Gehman,
J. Taylor,
T. Solosko,
J. Russell
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S31-S32
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Relation between electrocardiographic repolarization changes and left ventricular filling pressure evaluated by Doppler echocardiography in patients with hypertensive heart disease
It has been shown that compared with voltage-only criteria without any electrocardiographic repolarization changes for detecting left ventricular hypertrophy, composite criteria including the presence...
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Yuji Kasamaki,
Takeshi Yamada,
Kenichi Hashimoto,
Toshiko Nakai,
Ichiro Watanabe,
Satoshi Saito,
Yukio Ozawa
et al.
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S32
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Automated QT measurements for moxifloxicin and physiologic challenge in healthy volunteers
Results for study 3, where N = 60:
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James Lindauer,
Marilyn Agin,
Thomas Stock
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S32
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Computer and cardiologist diagnosis of ST-elevation myocardial infarction
Recognition of acute ST-elevation myocardial infarction (STEMI) is central to the new Guidelines for Acute Cardiac Care. The European Society of Cardiology/American College of Cardiology (ESC/ACC) hav...
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Peter W. Macfarlane,
David R. Hampton,
Elaine Clark,
Brian Devine,
Cynthia P. Jayne
et al.
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S32-S33
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Development of a QT-interval measurement program for 12-lead, 24-hour Holter electrocardiogram and its evaluation
To measure QT dispersion for 24 hours, we need to use 12-lead Holter electrocardiograms. The purpose of this study was to develop a QT-interval measurement program for a 24-hour Holter electrocardiogr...
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N. Mamorita,
H. Hara,
A. Takeuchi,
M. Shirataka,
H. Goto,
H. Miyahara,
N. Ikeda
et al.
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S33
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Advanced pacemaker detection
GE Healthcare has developed a new electrocardiogram (ECG) acquisition module and pacemaker pulse detection algorithm that increases the electrocardiograph's sensitivity to detect low-voltage pacemaker...
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Anthony Ricke,
Wesley Haisty,
Scott Kroegerc,
Steve Swiryn,
Brian Young
et al.
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S33
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Estimating heart rate turbulence from a single ectopic beat with robust processing
Heart rate turbulence (HRT) is defined as the increase and subsequent deceleration of the heart rate after a premature ventricular complex (PVC). Current HRT measurements require a number of PVC, whic...
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Óscar Barquero-Pérez,
José Luis Rojo-Álvarez,
Estrella Everss,
Ana Belén Rodríguez-González,
Arcadi García-Alberola
et al.
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S33-S34
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Lead selection methods from multilead electrocardiographic recordings
Definition of limited lead sets optimized for the study of specific clinical conditions can be achieved by multilead recordings. Different algorithms for lead selection are proposed, and their perform...
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M. Salud Guillem,
Francisco Castells,
Andreu M. Climent,
Francisco Javier Chorro-Gascó,
Vicent Bodí,
Jose Millet
et al.
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S34
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Prognostic significance of transient right axis deviation in patients with ST-segment elevation myocardial infarction treated with primary percutaneous intervention
There is a paucity of data regarding prognostic significance of transient right axis deviation in patients with acute anterior wall myocardial infarction (AWMI) treated with primary percutaneous inter...
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Nikolas Wanahita,
Kunal Shah,
Yumiko Kanei,
Meir Friedman,
Jennifer Chen,
Luiza Petrie,
Paul Schweitzer,
Maurice Rachko
et al.
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S34
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Multiscale rhythmogenetic analysis in Brugada syndrome
Recently, genetic analysis has identified several genotypically distinct subgroups of patients with Brugada syndrome. The distinctions between the subgroups are clinically important because of differe...
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Vladimir Shusterman,
Raul Weiss,
Barry London
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S34-S35
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Effective P-wave detection for analyzing long-term changes in atrial activation
Electrocardiogram signal processing and analysis is mainly concentrated on QRS and T waves. Interest in the atrial activity has not been in the same level and thus P wave signal processing and detecti...
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Juho Väisänen,
Pentti Korhonen
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S35
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Optimizing electrode locations for detecting anterior myocardial infarction by analyzing properties of the sensitivity distributions
When monitoring cardiac activation and changes in it, one might want to concentrate the measurement on a certain area of the cardiac muscle. This region of interest (ROI) can be a whole ventricle or a...
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Juho Väisänen,
Jari Hyttinen,
Jaakko Malmivuo
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S35
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Improvement of the automated recognition of Brugada-type electrocardiogram by using the synthesized electrocardiogram
It has been reported that the morphological patterns of Brugada-type electrocardiogram (ECG) become more clear at the higher intercostal space of right precordial leads (V1 to V2, V3) (HICS-ECG). The ...
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Tatsuya Yoneyama,
Mutuo Kaneko,
Takashi Yamaki,
Norimoto Isobe,
Toshihiko Nanke,
Kiyoshi Nakazawa,
Tsuneharu Sakurai,
Ryoji Kishi,
Yoshihiko Miyake,
Noboru Okamoto,
Yoshihiko Watanabe
et al.
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S35-S36
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| ISCE 2007 Session II: Computer Simulations: From Ion-Channels to the Electrocardiogram |
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Article Title |
Author(s) |
Pages |
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Regulation of ion channels and arrhythmias in the ischemic heart
Abstract: Ventricular arrhythmias in the setting of ischemic heart disease is a leading cause of mortality in the United States. A better understanding of the complex changes associated with ischemic ...
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Joseph G. Akar,
Fadi G. Akar
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S37-S41
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Impact of ancillary subunits on ventricular repolarization
Abstract: Voltage-gated potassium (Kv) channels generate the outward K+ ion currents that constitute the primary force in ventricular repolarization. Voltage-gated potassium channels comprise tetramer...
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Geoffrey W. Abbott,
Xianghua Xu,
Torsten K. Roepke
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S42-S46
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Genetic mutations and arrhythmia: simulation from DNA to electrocardiogram
Abstract: In the past two decades, mutations in cardiac ion channels have been shown to underlie a number of rare inherited cardiac arrhythmias. Defects in cardiac Na+ channels can disrupt channel gat...
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Zheng I. Zhu,
Colleen E. Clancy
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S47-S50
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Cardiac electrical dynamics: maximizing dynamical heterogeneity
Abstract: The relationships between key features of the cardiac electrical activity, such as electrical restitution, discordant alternans, wavebreak, and reentry, and the onset of ventricular tachyarr...
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Robert F. Gilmour,
Anna R. Gelzer,
Niels F. Otani
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S51-S55
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| ISCE 2007 Session III: Modeling and Imaging Arrhythmias, Fibrillation, and Defribillation |
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Article Title |
Author(s) |
Pages |
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Imaging ventricular fibrillation
Abstract: Ventricular fibrillation (VF) had been traditionally considered as a highly disorganized process of random electrical activity emanating from multiple, short-lived, reentrant electrical wave...
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Guy Salama,
Bum-Rak Choi
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S56-S61
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Imaging fibrillation/defibrillation in a dish
Abstract: Background: Sheets of cultured cardiac cells constitute an emerging experimental model of cardiac tissue electrophysiology and arrhythmia. It has been used to study fundamental properties of...
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Leslie Tung,
Joshua Cysyk
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S62-S65
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Acetylcholine-induced shortening of the epicardial action potential duration may increase repolarization gradients and LQT3 arrhythmic risk
Abstract: Unlike other variants of long QT syndrome, LQT3 patients are particularly susceptible to cardiac events during sleep. Changes in heart rate alone fail to fully account for this phenomenon. W...
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Sarah N. Flaim,
Andrew D. McCulloch
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S66-S69
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Eight (or more) kinds of alternans
Abstract: Cardiac electrical alternans is an alternating rhythm in the electrical properties of the heart, such as cellular action potential duration, conduction velocity, and/or intracellular calcium...
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Alan Garfinkel
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S70-S74
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Photon scattering effects in optical mapping of propagation and arrhythmogenesis in the heart
Abstract: Background: Optical mapping is a widely used experimental tool providing high-resolution recordings of cardiac electrical activity. However, the technique is limited by signal distortion due...
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Martin J. Bishop,
David J. Gavaghan,
Natalia A. Trayanova,
Blanca Rodriguez
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S75-S80
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Repeatability of T-wave morphology measurements: superiority of a principal component analysis–based lead
Repeatability of measurements is an important requirement for computerized T-wave morphology analysis. Leading morphology algorithms rely on calculation of T-wave shape from, for example, leads II or ...
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Mads P. Andersen,
Joel Xue,
Claus Graff,
Thomas B. Hardahl,
Michael Christiansen,
Egon Toft,
Jørgen K. Kanters,
Johannes J. Struijk
et al.
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S81
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Early stage of hypertrophy development in spontaneously hypertensive rats is characterized by decrease in QRS amplitude and attenuated expression of connexin 43
Previously, we have reported a decrease in QRS amplitude at the stage of developing left ventricular hypertrophy (LVH). We hypothesize that this decrease is conditioned by changes in electrogenic prop...
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Ljuba Bacharova,
Jana Plandorova,
Jan Klimas,
Peter Krenek,
Jan Kyselovic
et al.
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S81
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The first forty milliseconds: lessons from vectorcardiography
The initial forces of ventricular depolarization often differ from the mean QRS vector. The mean QRS vector is often considered only in the frontal plane. Consideration of the 3-dimensional vector lea...
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Robert M. Farrell,
Joel Q. Xue
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S81-S82
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A comparison of general and disease-specific lead sets in limited-lead body surface potential mapping
Body surface potential maps (BSPMs) can effectively capture all electrocardiographic information that is projected onto the body surface. Although capturing more information than conventional recordin...
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Dewar D. Finlay,
Chris D. Nugent,
Mark P. Donnelly,
Paul J. McCullagh,
Norman D. Black
et al.
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S82
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Diagnostic criterion of QT prolongation for healthy young Japanese men
It is important to exclude the cases with QT interval prolongation in advance to keep the cardiac safety of subjects in a phase 1 clinical trial for investigational drugs. To accomplish this purpose, ...
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Hiroshi Goto,
Noritaka Mamorita,
Akihiro Takeuchi,
Noriaki Ikeda,
Masuo Shirataka,
Hideo Miyahara
et al.
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S82
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T-wave convexity measure outperforms notch criterion as diagnostic marker for the HERG genotype
The congenital long QT syndrome (LQTS) typically presents a prolonged QT interval on electrocardiogram. In addition, various forms of LQTS show different morphological abnormalities of the T wave, whi...
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Claus Graff,
Joel Xue,
Mads P. Andersen,
Jørgen K. Kanters,
Thomas B. Hardahl,
Egon Toft,
Michael Christiansen,
Johannes J. Struijk
et al.
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S82-S83
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Cardiac resynchronization therapy augments T-wave alternans
Biventricular (BV) pacing has been shown to be effective in selected patients with left ventricular (LV) dysfunction. However, BV does not necessarily decrease sudden cardiac death. Recent studies hav...
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Kenichi Hashimoto,
Yuji Kasamaki,
Sonoko Ashino,
Masayoshi Kofune,
Yasuo Okumura,
Takeshi Yamada,
Tatsuya Kofune,
Kimie Ohkubo,
Atsushi Shindo,
Hidezou Sugimura,
Toshiko Nakai,
Ichiro Watanabe,
Yukio Ozawa,
Satoshi Saito
et al.
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S83
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A novel DICOM-based 12-lead electrocardiogram documentary system
Twelve-lead electrocardiograph (ECG) is one of the most often used diagnostic tools in clinical cardiac medicine. However, the development of a computerized ECG documentary system in e-hospitals is im...
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Jui-chien Hsieh
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S83
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The high-frequency QRS induced by acute myocardium infarction: computer simulations
Recent research has indicated a better approach to identifying acute myocardium infarction (AMI) by recognizing the high frequency QRS of an electrocardiogram (ECG). However, this approach is limited ...
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Jui-chien Hsieh
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S83
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Biopotential fiber sensors increase the sensitivity of ST-segment measurements in electrocardiographic stress testing
Obtaining accurate ST-segment measurements during stress testing in obese patients is a well-known challenge. Even with adequate skin preparation and electrode design and placement, the noise artifact...
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S.M. Lobodzinski,
M.M. Laks
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S83-S84
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Changes in T-wave amplitude in patients with peripheral edema: implications for patients with congestive heart failure and assessment of the T-wave alternans
Peripheral edema (PERED) leads to attenuation of the amplitude of the P waves and QRS complexes; thus, it was hypothesized that attenuation would also occur in the amplitude of the T waves with PERED.
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John E. Madias
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S84
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Experienced clinicians improve auscultatory detection of third and fourth heart sounds by adding phonocardiography
Phonocardiography is the criterion standard for detecting diastolic heart sounds. We examined whether visual inspection of phonocardiographic tracings augments the accuracy of medical students' and ph...
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Brian Moyers,
Andrew D. Michaels
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S84
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Magnetophysiologic phenotype of patients with arrhythmogenic right ventricular cardiomyopathy with ventricular tachyarrhythmias
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disorder that predominantly affects the right ventricle. It is a common cause of sudden cardiac death in adolescents and young adults. Cardi...
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Alexander Schirdewan,
Andrej Gapelyuk,
Robert Fischer,
Lydia Koch,
Henry Schütt,
Udo Zacharzowsky,
Nils Wessel,
Rainer Dietz
et al.
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S84-S85
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Timing and duration of electrocardiographic abnormalities after subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) is a catastrophic neurologic event that is frequently associated with electrocardiographic (ECG) abnormalities unexplained by preexisting cardiac disease. The purpose of ...
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Claire E. Sommargren,
Jonathan G. Zaroff,
Barbara J. Drew
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S85
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Validation and user manual creation for SuperECG program
SuperECG is a specialized computer software program used by clinical researchers to analyze and interpret raw data from a high-resolution 12-lead electrocardiogram (ECG). This software was developed b...
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Joshua M. Thomas,
Mary G. Carey
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S85
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Transfer matrices for deriving the vectorcardiogram: a consumer guide
In the literature, several different transfer matrices have been presented for deriving the vectorcardiogram (VCG) from the signals observed using a limited set of electrodes. Even when the electrode ...
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Adriaan van Oosterom,
Zenichi Ihara,
Rudi Hoekema
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S85-S86
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QRS-T angle for detecting left ventricular systolic dysfunction
Electrocardiographic (ECG) abnormalities of depolarization and repolarization have been shown to be associated with left ventricular enlargement. However, not all evidence of ventricular enlargement i...
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Robert A. Warner,
Patricia A. Arand,
Andrew D. Michaels
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S86
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Using model-based approach to study reduced-lead-set electrocardiogram
The continuous 12-lead electrocardiographic (ECG) patient-monitoring and telemetry technique is very useful for monitoring evolving ischemia events. In the meantime, using fewer electrodes in those lo...
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Yao Chen,
Weihua Gao,
Xiaodong Han,
Joel Xue
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S86
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Alternate gold standard of QT-interval and T-wave morphology measurements: a modeling approach
Studies have shown that the increase in heterogeneity during repolarization has higher correlation with torsades de pointes than QT prolongation itself. A challenge issue we have to address is what el...
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Joel Xue,
Yao Chen,
Weihua Gao,
Xiaodong Han,
Ian Rowlandson
et al.
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S87
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| ISCE 2007 Session IV: Presentations From Submitted Abstracts |
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Article Title |
Author(s) |
Pages |
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Documented narrow QRS tachycardia not inducible during electrophysiology study: should we modify the AV node or not
Abstract: Ablation therapy is the widely accepted definitive therapy for atrioventricular reentry tachycardia. Noninducibility of the tachycardia is the targeted end point of the procedure. We report ...
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Mathias Alexander Emmel,
Konrad Brockmeier,
Narayanswami Sreeram
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S88-S90
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Identifying coronary artery flow reduction and ischemia using quasistationary QT/RR-interval hysteresis measurements
Abstract: Because myocardial ischemia induces QT/RR hysteresis, a correlation was hypothesized to exist between the extent of myocardial flow reduction and the magnitude of QT/RR hysteresis. Graded re...
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Joseph M. Starobin,
Wayne E. Cascio,
Allan H. Goldfarb,
Vivek Varadarajan,
Andrei J. Starobin,
Christopher P. Danford,
Timothy A. Johnson
et al.
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S91-S96
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Identification of local myocardial repolarization time by bipolar electrode potential
Abstract: Purpose: The aim of this study was to investigate whether bipolar electrode potentials (BEPs) reflect local myocardial repolarization dynamics, using computer simulation. Methods: Simulated ...
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Tsunetoyo Namba,
Takahiro Todo,
Takenori Yao,
Takashi Ashihara,
Ryo Haraguchi,
Kazuo Nakazawa,
Takanori Ikeda,
Tohru Ohe
et al.
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S97-S102
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An algorithm for QT interval monitoring in neonatal intensive care units
Abstract: QT surveillance of neonatal patients, and especially premature infants, may be important because of the potential for concomitant exposure to QT-prolonging medications and because of the pos...
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Eric D. Helfenbein,
Michael J. Ackerman,
Pentti M. Rautaharju,
Sophia H. Zhou,
Richard E. Gregg,
James M. Lindauer,
David Miller,
John J. Wang,
Scott S. Kresge,
Saeed Babaeizadeh,
Dirk Q. Feild,
Francis P. Michaud
et al.
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S103-S110
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Activation patterns during selective pacing of the left ventricle can be characterized using noninvasive electrocardiographic imaging
Abstract: Background: Noncontact endocardial mapping allows accurate beat-to-beat reconstruction of the reentrant pathway of ventricular tachycardia and improves outcomes after ablation. Several studi...
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Heather Joanne Shannon,
Cesar O. Navarro,
Bernie A. Smith,
Anthony J. McClelland,
Ernest W. Lau,
Michael J.D. Roberts,
John M.C. Anderson,
Jeninifer A. Adgey
et al.
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S111-S117
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| ISCE 2007 Session V: Developments in Device Management of Cardiac Arrhthmias |
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Article Title |
Author(s) |
Pages |
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Global public health problem of sudden cardiac death
Abstract: Cardiovascular disease is a leading cause of global mortality, accounting for almost 17 million deaths annually or 30% of all global mortality. In developing countries, it causes twice as ma...
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Rahul Mehra
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S118-S122
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Detection of cardiac tachyarrhythmias in implantable devices
Abstract: Implantable devices such as pacemakers and implantable cardioverter/defibrillators (ICDs) use algorithms to sense cardiac depolarizations and to detect tachyarrhythmias by analysis of timing...
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Jeffrey Gillberg
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S123-S128
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Impaired T-amplitude adaptation to heart rate changes identifies IKr inhibition in the congenital and acquired form of the long QT syndrome
The QTc interval prolongation is not a perfect surrogate marker of the presence of an increased risk for arrhythmic events. In the congenital form of the long QT syndrome (LQTS), 10% to 15% of patient...
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Jean-Philippe Couderc,
Martino Vaglio,
Xiajuan Xia,
Scott McNitt,
Pierre Wicker,
Nenad Sarapa,
Arthur J Moss,
Wojciech Zareba
et al.
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S129
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Using the European Society of cardiology ST database to compare 2 automated methods for ST episode measurement
An effective way to evaluate ST measurements and episodes is critically needed. One solution is the European Society of Cardiology's (ESC) ST Database. As supplied, this database fails to fully meet t...
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Dirk Feild
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S129
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