Mega-epsilon waves on 12-lead ECG—just another case of arrhythmogenic right ventricular dysplasia/cardiomyopathy?☆
Introduction
The epsilon wave, the post-excitation small squiggles at the beginning of ST segment that first named by Fontaine,1 is a well-known ECG phenomenon mostly seen in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). Epsilon waves are caused by delayed excitation of the patches of myocardium in the right ventricle due to myocardial scaring. Increasing evidence suggests that cardiac sarcoidosis might produce the pathological substrate required for production of epsilon waves.2., 3., 4.
Here we report a case demonstrating mega-epsilon waves, right ventricular dilatation, and inducible ventricular tachycardia (VT) that was initially diagnosed as ARVD/C according to the Task Force Criteria. However after a thorough evaluation, a diagnosis of cardiac sarcoidosis was confirmed by endomycardial biopsy.
Section snippets
Case
A 46-year-old African-American man, having been in excellent health until age 45, began to develop shortness of breath on exertion. The initial 2-D echocardiogram was normal and the exercise ECG showed no inducible ischemia. He was treated to relieve symptoms and was advised to have periodic follow-up. Over the next one year, his symptoms progressively worsened, requiring further evaluation and treatment.
Medical history: this patient had no history of chest pain, paroxysmal nocturnal dyspnea,
Discussion
Sarcoidosis is a chronic multisystem disorder of unknown etiology characterized by the accumulation of T lymphocytes and mononuclear phagocytes, non-caseating granulomas and derangement of normal tissue architecture. The development of sarcoidosis is probably the end result of immune responses to various environmental triggers. Seen in men and women of all races worldwide, the prevalence of sarcoidosis in the United States among black Americans is roughly three times higher than that among
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Grant: AHA0735474N.