Journal of Electrocardiology
Volume 43, Issue 3 , Pages 261-263 , May 2010

Open-loop, clockwise QT-RR hysteresis immediately before the onset of torsades de pointes in type 2 long QT syndrome

  • Gen Nakaji, MD

      Affiliations

    • Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    • ,
  • Masahiko Fujiwara, MD

      Affiliations

    • Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    • ,
  • Mitsuhiro Fukata, MD

      Affiliations

    • Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    • ,
  • Shioto Yasuda, MD

      Affiliations

    • Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    • ,
  • Keita Odashiro, MD

      Affiliations

    • Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    • ,
  • Toru Maruyama, MD

      Affiliations

    • Institute of Health Science, Kyushu University, Kasuga, Japan
    • Corresponding Author InformationCorresponding author. Institute of Health Science, Kyushu University, Kasuga 816-8580, Japan.
    • ,
  • Koichi Akashi, MD

      Affiliations

    • Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

Received 2 October 2009

References 

  1. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell. 1995;80:795
  2. Yasuda S, Hiramatsu S, Odashiro K, Maruyama T, Tsuji K, Horie M. A family of hereditary long QT syndrome caused by Q738X HERG mutation. Int J Cardiol [Electronic publication ahead of print].
  3. Sundaram S, Carnethon M, Polito K, Kadish AH, Goldberger JJ. Autonomic effects on QT-RR interval dynamics after exercise. Am J Physiol. 2008;294:H490
  4. Malik M, Hnatkova K, Sisakova M, Schmidt G. Subject-specific heart rate dependency of electrocardiographic QT, PQ, and QRS intervals. J Electrocardiol. 2008;41:491
  5. Genovesi S, Zaccaria D, Rossi E, Valsecchi MG, Stella A, Stramba-Badiale M. Effects of exercise training on heart rate and QT interval in healthy young individuals: are there gender differences?. Europace. 2007;9:55
  6. Malik M, Hnatkova K, Novotny T, Schmidt G. Subject-specific profiles of QT-RR hysteresis. Am J Physiol. 2008;295:H2356
  7. Krahn AD, Yee R, Chauhan V, et al. Beta blockers normalize QT hysteresis in long QT syndrome. Am Heart J. 2002;143:528
  8. Suto F, Zhu W, Chan A, Gross GJ. IKr and IKs remodeling differentially affects QT interval prolongation and dynamic adaptation to heart rate acceleration in bradycardic rabbits. Am J Physiol. 2007;292:H1782

PII: S0022-0736(09)00624-4

doi: 10.1016/j.jelectrocard.2009.12.005

Journal of Electrocardiology
Volume 43, Issue 3 , Pages 261-263 , May 2010

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