Comparison of high-frequency QRS components and ST-segment elevation to detect and quantify acute myocardial ischemia☆☆☆
Received 13 October 2009 published online 11 January 2010.
Abstract
Objective
This study tests the ability of high-frequency components of the depolarization phase (HF-QRS) vs conventional ST-elevation criteria to detect and quantify myocardial ischemia.
Methods
Twenty-one patients admitted for elective percutaneous coronary intervention were included. Quantification of the ischemia was made by myocardial scintigraphy. High-resolution electrocardiogram before and during percutaneous coronary intervention was recorded and signal averaged. The HF-QRS were determined within the frequency band 150 to 250 Hz. ST-segment deviation was measured in the standard frequency range (<100 Hz).
Results
HF-QRS criteria were met by 76% of the patients, whereas 38% met the ST-elevation criteria (P = .008). Both HF-QRS reduction and ST elevation correlated significantly with the amount of ischemia (HF-QRS: r = 0.59, P = .005 for extent and r = 0.69, P = .001 for severity; ST elevation: r = 0.49, P = .023 for extent and r = 0.57, P = .007 for severity).
Conclusions
This study suggests that HF-QRS analysis could provide valuable information both to detect acute ischemia and to quantify myocardial area at risk.
☆ This study was supported by the American Heart Association, Durham, North Carolina, USA (account 5-21628), The South-Eastern Region of Healthcare, and the Blekinge Scientific Council, Sweden.
☆☆ This study is a part of the STAFF Studies Investigations.
ABSTRACT