Journal of Electrocardiology
Volume 43, Issue 1 , Pages 8-14 , January 2010

QT dynamicity, microvolt T-wave alternans, and heart rate variability during 24-hour ambulatory electrocardiogram monitoring in the healthy newborn of first to fourth day of life

  • Leonid Makarov

      Affiliations

    • Center for Syncope and Cardiac Arrhythmias in Children and Adolescents of the Federal Medical-biological Agency of Russia, Children's Clinical Hospital No. 38 of FMBA of Russia, Moscow, Russia
    • Corresponding Author InformationCorresponding author. Center for Syncope and Cardiac Arrhythmias in Children and Adolescents of the Federal Medical-biological Agency of Russia, Children's Clinical Hospital No. 38 of FMBA of Russia, Moscow, 115409 Russia.
    • ,
  • Vera Komoliatova

      Affiliations

    • Center for Syncope and Cardiac Arrhythmias in Children and Adolescents of the Federal Medical-biological Agency of Russia, Children's Clinical Hospital No. 38 of FMBA of Russia, Moscow, Russia
    • ,
  • Svetlana Zevald

      Affiliations

    • Maternity Hospital No. 15 of Moscow Healthcare Department, Moscow, Russia
    • ,
  • George Schmidt

      Affiliations

    • Department of Noninvasive Electrophysiology of the Centre of Heart Diseases, Technological University, Munich, Germany
    • ,
  • Аlexander Muller

      Affiliations

    • Department of Noninvasive Electrophysiology of the Centre of Heart Diseases, Technological University, Munich, Germany
    • ,
  • Victor Serebruany

      Affiliations

    • Johns Hopkins University Baltimore, Maryland, USA

Received 10 September 2009

References 

  1. Nadkarni V, Larkin G, Peberdy M, et al. First documented rhythm and clinical outcome from in-hospital cardiac arrest among children and adults. JAMA. 2006;295:50
  2. Bajanowski T, Borggrefe M, Brinkmann B, et al. De novo mutation in the SCN5A gene associated with early onset of sudden infant death. Circulation. 2001;104:1158
  3. Chang CC, Acharfi S, Wu MH, et al. A novel SCN5A mutation manifests as a malignant form of long QT syndrome with perinatal onset of tachycardia/bradycardia. Cardiovasc Res. 2004;64:268
  4. Horigome H, Iwashita H, Yoshinaga M, Shimisu W. Magnetocardiographic demonstration of Torsade de Pointes in a fetus with congenital long QT syndrome. J Cardiovasc Electrophysiol. 2008;19:334
  5. Southall D, Richards J, de Swiet M, et al. Identification of infant destined to die unexpectedly during infancy: evaluation of predictive importance of prolonged apnea and disorders of cardiac rhythm or conduction. First report of a multicentred prospective study into the sudden infant death syndrome. Br Med J. 1983;286:1092
  6. Nagashima H, Masushima M, Oqawa A, et al. Cardiac arrhythmias in healthy children revelated by 24-hour ambulatory ECG monitoring. Pediatr Cardiol. 1987;8:103
  7. Verrier RL, Nearing BD, Kwaku K. Noninvasive sudden death risk stratification by ambulatory ECG-based T-wave aletrnans analysis: evidence and methodological guidelines. Ann Noninvasive Electrocardiol. 2005;10:110
  8. Bauer A, Malik M, Schmidt G, et al. Heart rate turbulence: standards of measurement, physiological interpretation, and clinical use: International Society for Holter and Noninvasive Electrophysiology Consensus. J Am Coll Cardiol. 2008;52:1353
  9. Zipes D, Camm J, Borggrefe M, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Circulation. 2006;114:385
  10. Bauer A, Rantelhardt J, Schneider R, et al. Deceleration capacity of heart rate as a predictor of mortality after myocardial infarction: cohort study. Lancet. 2006;367:1674
  11. In:  Deal B,  Wolf G,  Gelband H editor. Current concepts in diagnosis and management of arrhythmias in infants and children. NY: Futura Pbl Co; 1998;p. 438
  12. In:  Zeigler V,  Gilette P editor. Practical management of pediatric cardiac arrhythmias. NY: Futura Pbl Co; 2001;p. 422
  13. Merri M, Moss A, Benhorin J, et al. Relation between ventricular repolarization duration and cardiac cycle length during 24-hour Holter recordings: findings in normal patients and patients with long QT syndrome. Circulation. 1992;85:1816
  14. Jensen B, Larroude Ch, Rasmussen L, et al. Beat-to-beat QT dynamics in healthy subjects. Ann Noninvasive Electrocardiol. 2004;9:3
  15. Zareba W, Bayes de Luna A. QT dynamics and variability. Ann Noninvasive Electrocardiol. 2005;10:256
  16. Cheron G, Lucet V, Montgermont P, Couly G. Development of the heart rate in the first year of life and infant ill health. Arch Fr Pediatr. 1986;43:475
  17. Böning U, Brodherr-Heberlein S, Schreiber R, Schumacher G, Bühlmeyer K. Extrasystole in the neonatal period. Geburtshilfe Frauenheilkd. 1985;45:803
  18. Schwartz P, Salice P. Cardiac arrhythmias in infancy: prevalence, significance and need for treatment. Eur Heart J. 1984;5(Suppl. B):43
  19. Southall DP, Orrell MJ, Talbot JF, et al. Study of cardiac arrhythmias and other forms of conduction abnormality in newborn infants. Br Med J. 1977;2:597
  20. Southall DP, Arrowsmith WA, Oakley JR, McEnery G, Anderson RH, Shinebourne EA. Prolonged QT interval and cardiac arrhythmias in two neonates: sudden infant death syndrome in one case. Arch Dis Child. 1979;54:776
  21. Yamada M, Nakazawa M, Momma K. Fetal ventricular tachycardia in long QT syndrome. Cardiol Young. 1998;8:119
  22. Hofbeck M, Ulmer H, Beinder E, Sieber E, Singer H. Prenatal findings in patients with prolonged QT interval in the neonatal period. Heart. 1997;77:198
  23. Menendez T, Achenbach S, Beinder E, et al. Prenatal diagnosis of QT prolongation by magnetocardiography. Pacing Clin Electrophysiol. 2000;23:1305
  24. Manning N, Anthony JP, Ostman-Smith I, Snyder CS, Burch M. Prenatal diagnosis and successful preterm delivery of a foetus with long QT syndrome. Br J Obstet Gynaecol. 2000;107:1049
  25. Donofrio MT, Gullquist SD, O'Connell NG, Redwine FO. Fetal presentation of congenital long QT syndrome. Pediatr Cardiol. 1999;20:441
  26. Mache CJ, Beitzke A, Haidvogl M, Gamillscheg A, Suppan C, Stein JI. Perinatal manifestations of idiopathic long QT syndrome. Pediatr Cardiol. 1996;17:118
  27. Trippel DL, Parsons MK, Gillette PC. Infants with long-QT syndrome and 2:1 atrioventricular block. Am Heart J. 1995;130:1130
  28. Ohkuchi A, Shiraishi H, Minakami H, Eguchi Y, Izumi A, Sato I. Fetus with long QT syndrome manifested by tachyarrhythmia: a case report. Prenat Diagn. 1999;19:990
  29. Schwartz PJ, Montemerlo M, Facchini M, et al. The QT interval throughout the first 6 months of life: a prospective study. Circulation. 1982;66:496
  30. Makarov L, Komoliatova V. Specific characteristics of QT dynamics in AECG monitoring in children and adolescents. In: Abstracts 13th Congress of the International Society for Holter and Noninvasive Electrocardiology (ISHNE). 4-6 June, Yokohama, Japan. 15:2009;p. S2
  31. Stein PK, Sanghavi D, Domitrovich PP, Mackey RA, Deedwania P. Ambulatory ECG-based T-wave alternans predicts sudden cardiac death in high-risk post-MI patients with left ventricular dysfunction in the EPHESUS study. J Cardiovasc Electrophysiol. 2008;19:1037
  32. Sakaki K, Ikeda T, Miwa Y, et al. Time-domain T-wave alternans measured from Holter electrocardiograms predicts cardiac mortality in patients with left ventricular dysfunction: a prospective study. Heart Rhythm. 2009;6:332
  33. Makarov L, Komoliatova V, Chuprova S. Microvolt T wave alternans during Holter monitoring in children and adolescents. In: Abstracts 13th Congress of the International Society for Holter and Noninvasive Electrocardiology (ISHNE). 4-6 June Yokohama, Japan. 2009;p. 92
  34. Nieminen T, Lehtimäki T, Viik J, et al. T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise test. Eur Heart J. 2007;28:2332
  35. Mehta SK, Super DM, Connuck D, et al. Heart rate variability in healthy newborn infants. Am J Cardiol. 2002;89:50
  36. Pandolfi M, Falsini G, Lazzerini S, et al. ECG monitoring in full-term infants. Analysis of the rhythm and variability of heart rate. Pediatr Med Chir. 1993;15:569
  37. Komoliatova V, Makarov L, Schmidt G, Muller A, Zevald S. Deceleration/acceleration capacity in children. In: Abstracts 13th Congress of the International Society for Holter and Noninvasive Electrocardiology (ISHNE). 4-6 June Yokohama, Japan. 2009;p. 199
  38. Griffin MP, Moorman JR. Toward the early diagnosis of neonatal sepsis and sepsis-like illness using novel heart rate analysis. Pediatrics. 2001;107:97
  39. Kovatchev BP, Farhy LS, Cao H, Griffin MP, Lake DE, Moorman JR. Sample asymmetry analysis of heart rate characteristics with application to neonatal sepsis and systemic inflammatory response syndrome. Pediatr Res. 2003;54:892
  40. Murase M, Ishida A, Morisawa T. Left and right ventricular myocardial performance index (Tei Index) in very-low-birth-weight infants. Pediatr Cardiol. 2009;30:928

PII: S0022-0736(09)00553-6

doi: 10.1016/j.jelectrocard.2009.11.001

Journal of Electrocardiology
Volume 43, Issue 1 , Pages 8-14 , January 2010

Article Tools

* Image Usage & Resolution