Journal of Electrocardiology
Volume 42, Issue 6 , Pages 505-510 , November 2009

Intracardiac QT variability in patients with structural heart disease on class III antiarrhythmic drugs

  • Larisa G. Tereshchenko, MD, PhD

      Affiliations

    • The Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
    • Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA
    • Corresponding Author InformationCorresponding author. The Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Carnegie 592, 600 N. Wolfe St., Baltimore, MD 21287, USA.
    • ,
  • Barry J. Fetics, MS

      Affiliations

    • The Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
    • ,
  • Ronald D. Berger, MD, PhD

      Affiliations

    • The Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA

Received 23 April 2009

References 

  1. The World Health Organization. The top 10 causes of death. Fact sheet N°310, Updated October 2008 http://www.who.int/mediacentre/factsheets/fs310/en/index.html, [Accessed on 3 July 2009].
  2. Paz O, Zhou X, Gillberg J, Tseng HJ, Gang E, Swerdlow C. Detection of T-wave alternans using an implantable cardioverter-defibrillator. Heart Rhythm. 2006;3:791
  3. Swerdlow CD, Zhou X, Voroshilovsky O, Abeyratne A, Gillberg J. High amplitude T-wave alternans precedes spontaneous ventricular tachycardia or fibrillation in ICD electrograms. Heart Rhythm. 2008;5:670
  4. Sandhu RK, Costantini O, Cummings JE, Poelzing S, Rosenbaum DS, Quan KJ. Intracardiac alternans compared to surface T-wave alternans as a predictor of ventricular arrhythmias in humans. Heart Rhythm. 2008;5:1003
  5. Tereshchenko LG, Fetics BJ, Domitrovich PP, Lindsay BD, Berger RD. Prediction of ventricular tachyarrhythmias by intracardiac repolarization variability analysis. Circ Arrhythmia Electrophysiol. 2009;2:276
  6. Wu L, Rajamani S, Shryock JC, et al. Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone. Cardiovasc Res. 2008;77:481
  7. Berger RD, Kasper EK, Baughman KL, Marban E, Calkins H, Tomaselli GF. Beat-to-beat QT interval variability: novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation. 1997;96:1557
  8. Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS. Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation. 1999;99:1385
  9. Nolasco JB, Dahlen RW. A graphic method for the study of alternation in cardiac action potentials. J Appl Physiol. 1968;25:191
  10. Diaz ME, O'Neill SC, Eisner DA. Sarcoplasmic reticulum calcium content fluctuation is the key to cardiac alternans. Circ Res. 2004;94:650
  11. Rosenbaum DS, Jackson LE, Smith JM, Garan H, Ruskin JN, Cohen RJ. Electrical alternans and vulnerability to ventricular arrhythmias. N Engl J Med. 1994;330:235
  12. Shusterman V, Goldberg A, London B. Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humans. Circulation. 2006;113:2880
  13. Abbott GW, Xu X, Roepke TK. Impact of ancillary subunits on ventricular repolarization. J Electrocardiol. 2007;40(6 Suppl):S42
  14. Miller GAH, Noble MIM, Papadoyannis D, Pidgeon J, Seed WA. A catheter-tip method for recording monophasic action-potentials from the canine or human endomyocardium. J Physiol (Lond). 1980;305:7
  15. Seed WA, Noble MI, Oldershaw P, et al. Relation of human cardiac action potential duration to the interval between beats: implications for the validity of rate corrected QT interval (QTc). Br Heart J. 1987;57:32
  16. Tanskanen AJ, Greenstein JL, O'Rourke B, Winslow RL. The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations. Biophys J. 2005;88:85
  17. Kodama I, Kamiya K, Toyama J. Amiodarone: ionic and cellular mechanisms of action of the most promising class III agent. Am J Cardiol. 1999;84:20R
  18. Kodama I, Kamiya K, Toyama J. Cellular electropharmacology of amiodarone. Cardiovasc Res. 1997;35:13
  19. Maltsev VA, Undrovinas AI. A multi-modal composition of the late Na+ current in human ventricular cardiomyocytes. Cardiovasc Res. 2006;69:116
  20. Maltsev VA, Silverman N, Sabbah HN, Undrovinas AI. Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability. Eur J Heart Fail. 2007;9:219
  21. Roden DM. Cellular basis of drug-induced torsades de pointes. Br J Pharmacol. 2008;154:1502
  22. Roden DM. Repolarization reserve: a moving target. Circulation. 2008;118:981
  23. Schrickel JW, Schwab JO, Yang A, Bitzen A, Luderitz B, Lewalter T. “Torsade de pointes” in patients with structural heart disease and atrial fibrillation treated with amiodarone, beta-blockers, and digitalis. Pacing Clin Electrophysiol. 2006;29:363
  24. Schrickel JW, Schwab JO, Yang A, et al. Pro-arrhythmic effects of amiodarone and concomitant rate-control medication. Europace. 2006;8:403
  25. Fenichel RR, Malik M, Antzelevitch C, et al. Drug-induced torsades de pointes and implications for drug development. J Cardiovasc Electrophysiol. 2004;15:475

PII: S0022-0736(09)00323-9

doi: 10.1016/j.jelectrocard.2009.07.011

Journal of Electrocardiology
Volume 42, Issue 6 , Pages 505-510 , November 2009

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