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Journal of Electrocardiology
Volume 43, Issue 1
, Pages 84-86
, January 2010
Optimum way to evaluate the quality of QT interval measurement in pharmaceutical studies
References
- . Exploring QT interval changes as a precursor to the onset of ventricular fibrillation/tachycardia. J Electrocardiol. 2009;42:374
- Takotsubo cardiomyopathy and QT interval prolongation: who are the patients at risk for torsades de pointes?. J Electrocardiol. 2009;42:353
- Comparison of QTinno, a fully automated electrocardiographic analysis program, to semiautomated electrocardiographic analysis methods in a drug safety study in healthy subjects. J Electrocardiol. 2009;42:358
- . Effects of vrapamil on anterior ST segment and ventricular fibrillation cycle length in patients with Brugada syndrome. J Electrocardiol. 2009;42:367
- . Intra- and interreader variability in QT interval measurement by tangent and threshold methods in a central electrocardiogram laboratory. J Electrocardiol. 2009;42:348
- E14 clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs. Guidance to industry. Fed Regist. 2005;70:61134
- Man versus machine: is there an optimal method for QT measurements in thorough QT studies?. J Clin Pharmacol. 2006;46:598
- . Comparison of manual and automated measurements of the QT interval in healthy volunteers: an analysis of five thorough QT studies. Clin Pharmacol Ther. 2009;[in press]
- . Nonlinear adaptive wavelet analysis of electrocardiogram signals. Phys Rev E Stat Nonlin Soft Matter Phys. 2007;76:026214
- . Delineation of T-wave in ECG by wavelet transform using multiscale differential operator. IEEE Trans Biomed Eng. 2006;53:1429
- . Automated QT analysis that learns from cardiologist annotations. Ann Noninvasive Electrocardiol. 2009;14(Suppl 1):S9
- . Errors and misconceptions in ECG measurement used for the detection of drug induced QT interval prolongation. J Electrocardiol. 2004;37(Suppl):25
- . Statistical issues including design and sample size calculation in thorough QT/QTc studies. J Biopharm Stat. 2008;18:451
- . Sample size, power calculations, and their implications for the cost of thorough studies of drug induced QT interval prolongation. Pacing Clin Electrophysiol. 2004;27:1659
- . Systematic comparisons of electrocardiographic morphology increase the precision of QT interval measurement. Pacing Clin Electrophysiol. 2009;32:119
- Thorough QT/QTc study in patients with advanced Parkinson's disease: cardiac safety of rotigotine. Clin Pharmacol Ther. 2008;84:595
- . Near-thorough QT study as part of a first-in-man study. J Clin Pharmacol. 2008;48:1146
PII: S0022-0736(09)00262-3
doi: 10.1016/j.jelectrocard.2009.06.018
© 2010 Elsevier Inc. All rights reserved.
« Previous
Journal of Electrocardiology
Volume 43, Issue 1
, Pages 84-86
, January 2010
