Journal of Electrocardiology
Volume 42, Issue 6 , Pages 549-554 , November 2009

Relationship between extracellular T-wave height, T-wave alternans amplitude, and tissue action potential alternans: a 1-dimensional computer modeling study

  • Ashish N. Doshi, BS

      Affiliations

    • Department of Biomedical Engineering, Duke University, Durham, NC, USA
    • Corresponding Author InformationCorresponding author. Department of Biomedical Engineering, Duke University, Box 90281, Durham, NC 27708-0281, USA.
    • ,
  • Salim F. Idriss, MD, PhD

      Affiliations

    • Department of Biomedical Engineering, Duke University, Durham, NC, USA
    • Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA

Received 29 May 2009

References 

  1. Narayan SM. T-wave alternans and the susceptibility to ventricular arrhythmias. J Am Coll Cardiol. 2006;47:269
  2. Pastore JB, et al. Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation. 1999;99:1385
  3. Yan GX, et al. Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations. Circulation. 1998;98:1921
  4. Fox JJ, et al. Ionic mechanism of electrical alternans. Am J Physiol Heart Circ Physiol. 2001;282:H516
  5. Mazzoleni AP. Conductivity values of tissue culture medium from 20°C to 40°C. Bioelectromagnetics. 1986;7:95
  6. Pormann JB. A Modular Simulation System for the Bidomain Equations (Thesis). Durham, NC: Duke University, 1999.
  7. Bloomfield DM, et al. Interpretation and classification of microvolt T wave alternans tests. J Cardiovasc Electrophysiol. 2002;13:502
  8. Madias JE. A proposal for a T-wave alternans index. J Electrocardiol. 2007;40:479
  9. Madias JE. Is there a relation between the magnitude of the microvolt T-wave alternans (MTWA) and the amplitude of the T wave(s) employed for MTWA calculation?. Am J Cardiol. 2008;101:554

☆ Financial support: American Heart Association Predoctoral Fellowship grant to the primary author.

PII: S0022-0736(09)00259-3

doi: 10.1016/j.jelectrocard.2009.06.012

Journal of Electrocardiology
Volume 42, Issue 6 , Pages 549-554 , November 2009

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