Journal of Electrocardiology
Volume 42, Issue 6 , Pages 549-554 , November 2009

Relationship between extracellular T-wave height, T-wave alternans amplitude, and tissue action potential alternans: a 1-dimensional computer modeling study

  • Ashish N. Doshi, BS

      Affiliations

    • Department of Biomedical Engineering, Duke University, Durham, NC, USA
    • Corresponding Author InformationCorresponding author. Department of Biomedical Engineering, Duke University, Box 90281, Durham, NC 27708-0281, USA.
    • ,
  • Salim F. Idriss, MD, PhD

      Affiliations

    • Department of Biomedical Engineering, Duke University, Durham, NC, USA
    • Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA

Received 29 May 2009

  • Image Result

    A, Position of positive and negative recording electrodes relative to fiber. (B) Steady-state APD of each node during APD alternans as a function of distance along the fiber. (C) Steady-state APD alte

    A, Position of positive and negative recording electrodes relative to fiber. (B) Steady-state APD of each node during APD alternans as a function of distance along the fiber. (C) Steady-state APD alternans magnitude during APD alternans as a function of distance along the fiber.

  • Image Result
    T-wave amplitude is directly measured from the ECG tracing. The TWA amplitude is calculated as the difference between the 2 T-wave amplitudes. The TWA index is calculated as TWA amplitude divided by T

    T-wave amplitude is directly measured from the ECG tracing. The TWA amplitude is calculated as the difference between the 2 T-wave amplitudes. The TWA index is calculated as TWA amplitude divided by T-wave amplitude of the short T wave.

  • Image Result
    Potential field surrounding fiber at the instant of the peak of the T wave, with isopotential lines shown in gray. A, Potential field at the peak of the shorter T wave during TWA. B, Potential field a

    Potential field surrounding fiber at the instant of the peak of the T wave, with isopotential lines shown in gray. A, Potential field at the peak of the shorter T wave during TWA. B, Potential field at the peak of the taller T wave during TWA.

☆ Financial support: American Heart Association Predoctoral Fellowship grant to the primary author.

PII: S0022-0736(09)00259-3

doi: 10.1016/j.jelectrocard.2009.06.012

Journal of Electrocardiology
Volume 42, Issue 6 , Pages 549-554 , November 2009

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