Logit50: A nonlinear transformation of pNN50 with improved statistical properties☆☆☆

Abstract

The traditional time domain heart rate variability index pNN50 is a percentage scale-based measure of large beat-to-beat changes in heart period that may reflect parasympathetic neural activity impinging on the sino-atrial node. However, pNN50 exhibits nonlinear saturation effects near 0% and 100% that may adversely affect its statistical properties. The purpose of this paper is to propose a revision of pNN50, Logit50, that is the natural logarithm of the odds of the occurrence of large beat-to-beat differences in R-R interval. Using five clinical and normal sample data sets, the revised Logit50 index is shown to retain the computational simplicity and interpretability of the pNN50, but to have better metric properties in statistical and clinical applications. In particular, the Logit50 is demonstrated to be relatively unaffected by the positive distributional skew that is common in most statistical applications of pNN50.

Keywords: Heart rate variability, heart period variability, autonomic nervous system, parasympathetic nervous system, research methods, statistical issues, ambulatory monitoring, Holter monitoring

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Article Outline

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References

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* Department of Biobehavioral Nursing and Health Systems

† School of Nursing, University of Washington, Seattle, WA

‡ School of Nursing, University of California at Los Angeles, CA

§ Department of Biobehavioral, Nursing and Health Systems, School of Nursing, and Division of Gastroenterology, School of Medicine, Seattle, WA.

☆ The methods comparisons presented in this study are based on five example data sets collected during research studies funded by the National Institutes of Health in projects NR01970 (M.J. Cowan, PI), HL60042 (S.A. Motzer, PI), NR04101 (M.M. Heitkemper, PI), and NR02429 (R.L. Burr, PI).

☆☆ Reprint requests: Robert L. Burr, MSEE, PhD, Research Associate Professor, Box 357265, University of Washington, Seattle, WA 98195-7265; e-mail: bobburr@u.washington.edu.

PII: S0022-0736(03)50001-2

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