Journal of Electrocardiology
Volume 36 , Pages 51-56 , December 2003

Upper limit of vulnerability in a defibrillation model of the rabbit ventricles

  • Blanca Rodrı́iguez, PhD

      Affiliations

    • Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA
    • ,
  • Natalia Trayanova, PhD

      Affiliations

    • Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA
    • Corresponding Author InformationReprint requests: Natalia Trayanova, PhD; Department of Biomedical Engineering, Lindy Boggs Suite 500, Tulane University, New Orleans, LA 70118, USA

References 

  1. Chen PS, Wolf PD, Claydon FJ, et al.  The potential gradient field created by epicardial defibrillation electrodes in dogs. Circulation. 1986;74:626
  2. Frazier DW, Wolf PD, Wharton JM, et al.  Stimulus-induced critical point (mechanism for electrical initiation of reentry in normal canine myocardium). Clin Invest. 1989;83:1039
  3. Efimov IR, Cheng Y, Van Wagoner DR, et al.  Virtual electrode-induced phase singularity (A basic mechanism of defibrillation failure). Circ Res. 1998;82:918
  4. Efimov IR, Cheng Y, Yamanouchi Y, et al.  Direct evidence of the role of virtual electrode-induced phase singularity in success and failure of defibrillation. J Cardiovasc Electrophysiol. 2000;11:861
  5. Efimov IR, Aguel F, Cheng Y, et al.  Virtual electrode polarization in the far field (implications for external defibrillation). Am J Physiol. 2000;279:H1055
  6. Lindblom AE, Aguel F, Trayanova NA. Virtual electrode polarization leads to reentry in the far field. J Cardiovas Electrophysiol. 2001;12:946
  7. Skouibine K, Trayanova NA, Moore P. Success and failure of the defibrillation shock (in-sights from a simulation study). J Cardiovasc Electrophysiol. 2000;11:785
  8. Trayanova NA, Eason JC, Aguel F. Computer simulations of cardiac defibrillation (A look inside the heart). Comput Visual Sci. 2002;4:259
  9. Vetter FJ, McCulloch AD. Three-dimensional analysis of regional cardiac function (A model of rabbit ventricular anatomy). Prog Biophys Molec Biol. 1998;69:157
  10. Henriquez CS. Simulating the electrical behavior of cardiac muscle using the bidomain model. Crit Rev Biomed Eng. 1993;21:1
  11. Trayanova NA, Skouibine K, Moore PK. Virtual electrode effects in defibrillation. Prog Biophys Mol Biol. 1998;69:387
  12. Efimov IR, Gray RA, Roth BJ. Virtual electrodes and deexcitation (new insights into fibrillation induction and defibrillation). J Cardiovasc Electrophysiol. 2000;11:339
  13. Entcheva E, Eason JC, Efimov IR, et al.  Virtual electrode effects in transvenous defibrillation-modulation by structure and interface (Evidence from bidomain simulations and optical mapping). J Cardiovasc Electrophysiol. 1998;9:949
  14. Cheng Y, Mowrey KA, Van Wagoner DR, Tchou PJ, Efimov IR. Virtual electrode induced re-excitation (A mechanism of defibrillation). Circ Res. 1999;85:1056

☆ This work was supported by NIH Grants HL063196 and HL067322, by grants from the Plan Nacional de Investigación Cientifica, Desarrollo e Innovación Technológica of the Ministerio de Ciencia y Tecnologı́a (Spain), and the Programa de Incentivo a la Investigación of the Universidad Politécnica de Valencia (Spain), and by a postdoctoral fellowship (CTESPP/2002/69) from the Oficina de Ciencia y Tecnologı́a de la Generalitat Valenciana (Spain)

PII: S0022-0736(03)00153-5

doi: 10.1016/j.jelectrocard.2003.09.066

Journal of Electrocardiology
Volume 36 , Pages 51-56 , December 2003

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