Journal of Electrocardiology
Volume 36 , Pages 1-5 , December 2003

Cellular basis for ST-segment changes observed during ischemia

  • José M Di Diego, MD

      Affiliations

    • Masonic Medical Research Laboratory, Utica, NY, USA
    • ,
  • Charles Antzelevitch, PhD

      Affiliations

    • Masonic Medical Research Laboratory, Utica, NY, USA
    • Corresponding Author InformationReprint requests: Charles Antzelevitch, Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13504, USA

References 

  1. Miller WT, Geselowitz DB. Simulation studies of the electrogram. 2. Ischemia and infarction. Circ Res. 1978;43:315
  2. Miller WT, Geselowitz DB. Simulation studies of the electrocardiogram. 1. The normal heart. Circ Res. 1978;43:301
  3. Mandel WJ, Burgess MJ, Neville J, et al.  Analysis of T-wave abnormalities associated with myocardial infarction using a theoretical model. Circulation. 1968;38:178
  4. Haws CW, Lux RL. Correlation between in vivo transmembrane action potential durations and action-recovery intervals from electrograms. Effects of interventions that alter repolarization time. Circulation. 1990;81:281
  5. Downar E, Janse MJ, Durrer D. The effect of acute coronary artery occlusion on subepicardial transmembrane potentials in the intact porcine heart. Circulation. 1977;56:217
  6. Ejima J, Martin D, Engle CL, et al.  Ability of activation recovery intervals to assess action potential duration during acute no-flow ischemia in the in situ porcine heart. J Cardiovasc Electrophysiol. 1998;9:832
  7. Childers R. R wave amplitude in ischemia, injury, and infarction. J Electrocardiol. 1996;29:171
  8. Madias JE. The earliest electrocardiographic signs of acute transmural myocardial infarction. J Electrocardiol. 1977;10:193
  9. Antzelevitch C, Brugada P, Brugada J, et al.  Brugada Syndrome (A Decade of Progress). Circ Res. 2002;91:1114
  10. Di Diego JM, Cordeiro JM, Goodrow RJ, et al.  Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males. Circulation. 2002;106:2004
  11. Kyndt F, Probst V, Potet F, et al.  Novel SCN5A mutation leading either to isolated cardiac conduction defect or Brugada syndrome in a large French family. Circulation. 2001;104:3081

☆ This work supported by grants HL37396 and HL47678 from the National Institutes of Health, a Grant-in-Aid from the American Heart Association, New York State Affiliate, and New York and Florida Masons.

PII: S0022-0736(03)00089-X

doi: 10.1016/j.jelectrocard.2003.09.001

Journal of Electrocardiology
Volume 36 , Pages 1-5 , December 2003

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